Noggin Gene Delivery Inhibits Cementoblast-Induced Mineralization

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Multi-Walled Carbon Nanotubes Promote Cementoblast Differentiation and Mineralization through the TGF-β/Smad Signaling Pathway

Excretion of cementum by cementoblasts on the root surface is a process indispensable for the formation of a functional periodontal ligament. This study investigated whether carboxyl group-functionalized multi-walled carbon nanotubes (MWCNT-COOH) could enhance differentiation and mineralization of mammalian cementoblasts (OCCM-30) and the possible signaling pathway involved in this process. Cem...

متن کامل

Noggin Inhibits Hypoxia-induced Proliferation by Targeting Store-operated Calcium Entry

Noggin Inhibits Hypoxia-induced Proliferation by Targeting Store-operated Calcium Entry 1 and Transient Receptor Potential Cation Channels 2 3 4 Kai Yang , Jing Jia, Jie Zhang, Mingming Zhao, Sabrina Wang, Haiyang Jiang, Lei Xu , 5 Wenju Lu and Jian Wang 2 6 7 Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Diseases, The 1 8 Affiliated Hospital of Guangzhou Medic...

متن کامل

Efficient in vitro delivery of Noggin siRNA enhances osteoblastogenesis

Several types of serious bone defects would not heal without invasive clinical intervention. One approach to such defects is to enhance the capacity of bone-formation cells. Exogenous bone morphogenetic proteins (BMP) have been utilized to positively regulate matrix mineralization and osteoblastogenesis, however, numerous adverse effects are associated with this approach. Noggin, a potent antag...

متن کامل

Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation.

BACKGROUND Recent studies have demonstrated that systemic pharmacological induction of heme oxygenase-1 (HO-1), the inducible isoform of the initial and rate-limiting enzyme for heme catabolism, attenuates neointima formation after experimental vascular injury. We have now investigated the ability of localized adenovirus-mediated HO-1 (Ad-HO-1) gene delivery to modify arterial remodeling after ...

متن کامل

NOGGIN: a new therapeutic target for PH? Focus on "Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels".

PULMONARY ARTERIAL HYPERTENSION (PAH) is a rare and often fatal disease characterized by sustained and progressive elevation of mean pulmonary arterial pressure with pathological changes involving vasoconstriction, vascular remodeling, and inflammation, leading to right ventricular hypertrophy and heart failure (6). Endothelial dysfunction and subsequent excessive proliferation of smooth muscle...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Connective Tissue Research

سال: 2004

ISSN: 0300-8207,1607-8438

DOI: 10.1080/03008200490278142